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Curing cancer? The dichloroacetate story

Maybe it seems to be a simple solution for curing cancer, but The E-cclesiastic Manifesto blog writes about a drug called dichloroacetate:

A team led by Dr. Evangelos Michelakis at the University of Alberta in Canada have figured out a new use for a safe, cheap chemical already used in medicine for a host of metabolic disorders. This chemical is Dichloroacetate (DCA), and it turns cancer into an angsty, suicidal teenager… the drug must go through the laborious, sisyphic and prohibitively expensive (~ $800m) process of gaining FDA approval. In the case of a drug that needs to be tested on nearly every single type of cancer the process would run into the multiple billions.

This means that no pharmaceutical company is going to get this drug FDA approved, especially since it also makes some of their less effective patented drugs worthless. As a matter of fact, they’ll probably lobby against it with all their might.

But never forget about a possible post-reaction just like in this case as Respectful Insolence commented the story (without using a beta-blocker): Dichloroacetate: One last time… But he writes in the original article that:

So where do I put on my pharma shill hat? Patience, dear readers… This drug has only been tested in cell culture and rats. Yes, the results were promising there, but that does not–I repeat, does not– mean the results will translate to humans.

I’ll follow the reply posts on the subject and will let you know when something important happens.

med5.jpg

Update from the comments:

Update of the update:

Update of September:

  • Health Canada has approved the first human trial of an experimental cancer drug called dichloroacetate, or DCA, in people with an advanced form of an aggressive brain cancer.

Update of October:

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138 Comments Post a comment
  1. greg #

    As far as I’m concerned it’s pretty irresponsible to say that DCA is a miracle (according to other blogs and articles on the web), especially without any human test results. I’m not a cancer expert, but I think that – as in many research fields, in pharmacy as well – without any acceptable and authentic evidence – in this case that would be long lasting and as mentioned expensive human drug experiments – it’s just Dr. Michelakis way to make a big splash. (Maybe he’s just competing to Nobel price :D )

    Another interesting fact is not mentioned in the most articles. DCA can cause pain, numbness and gait disturbances in some patients.

    January 31, 2007
    • I was diagnosed with stage 4E Mantle cell lymphoma on Feb 1, 2007. I was given 6 months to 18 months to live with or without chemo bu the UC Ohio Oncology dept. I took DCA from May 2007 until Oct.2007 since I had no hope at that point. My bone marrow was 50% compromised with lymphoma and I had huge nodes throughout my body in my abdomen and pelvic areas, I had severe bone pain (nerves on the sheath of the bones caused from swelling within the bones), I had tenitis, severe sounds of chain saw like sound, or like mini bikes, that kept me awake most all night so a lack of sleep too. I had numbness on the left side of my face and jaw bone pain which was severe. I had night and day sweats. I had edema around my waist. BUT, once i began taking the DCA, all the symptoms went away. By the 4th month being on DCA, I ran out and couldn’t find more. The DCA did cause a minor amount of neuropothy in my fingers and toes, but as soon as I went off of the DCA, the neuropothy went away. I had also been taking B vitamine to counteract the numbness, which helped very little. HOWEVER, Vinchristine, used in R-CHOP, also caused neuropothy, only problem with vinchristine is, neuropothy doesn’t go away after you stop taking it, the sensory nerves are permanantly damaged and the nerves have to grow back and that takes years. DCA on the otherhand, the neuropothy goes away as soon as the DCA is out of your system. I went through R-CHOP, stem cell harvesting, and extensive chemo, then a BMT and was released from the Hospital on May 20th, 09 Cancer free. Amazingly, the bone marrow that previously was 50% compromised had been cleared and there was no lymphoma in my bone marrow after the 4 months of taking the DCA. When I could not get DCA in November 2007, I noticed a node in my neck, the cancer had begun to grow again so I had another bone marrow aspiration and my bone marrow had no lymphoma. The DCA cleared that up, eliminated all my symptoms, and then I went through the BMT to clean up the rest of the mantle cell lymphoma stage 4. I am a success story! I am today cancer free and a true believer in DCA. Stick that in your pipe and smoke it. Do you work for the FDA? I’m sure any oncologist with a heart would love to use DCA but the Stage 3 human trials are so expensive, no one would be able to make their money back. Shame on them. Shame on Big Pharmeceuticle companies and the oncologists killing needlessly people who are too weak for extensive chemo, our elderly, our young. Shame on them! DCA does work. I am a human and I tried it, and it worked. Isn’t it just unnerving that a simple and inexpensive product like DCA can do so much good and all because of the FDA, people at the end of their rope are not permitted to self treat with such a wonderful chemical. You can’t get high on it, there is nothing recreational about it at all, just the possibility of living. Staying alive was my first priority so I used it, and I did live. Even my oncologist that refused to believe in DCA back in 2007 admitted to me that I was definately onto something. Well, do you think? He gave me 6 months to live feb. 01, 2007, and here it is Jan. 2010. I’m alive.

      January 27, 2010
      • Phyllis~ #

        Hi, Judy~ I agree with you, and have for quite sometime, about the FDA and AMA controlling our rights to recieving various optional treatments because of the financial aspect. I learned about a substance years ago, called Fluosol which is a blood replacer that has had remarkable success when used in place of blood tranfusions. But the same thing holds true of the acceptance of that substance by the various medical organizations. Free country!? Maybe. But we sure are blocked to some better medical remedies by the medical profession due to their fear of losing some of their financial gains. Oh, well. Just so glad that some people, like you, have and are, being able to be helped through some other channels of healing~ Thank you so much for printing your story. Shows there still is hope for others~ *smile*

        May 3, 2010
      • robin #

        hello
        it good to hear your experience ,could u suggest the dose of dca and how do i get it in india

        robin

        May 8, 2010
      • Dear Judy,

        My wife has AAIII, diagnosed in April 2009. She had surgery, chemo and radio. The tumor shranked 35% and she is doing fine. Having read many good things about DCA and your testimony, she really wants to try the DCA as you did and I am kindly requesting the following information from you. You will be saving a life if you could answer me:

        1) where did you buy the DCA?
        2) what dosage did you use and how (pills or intravenis)?

        Please reply to my personal e-mail:

        t.temel@uvt.nl

        I am impressed with your testimony and this DCA may be the cure many are waiting…

        Kind regards,
        Tugrul

        May 19, 2010
      • Dear Judy,

        My wife has AAIII, diagnosed in April 2009. She had surgery, chemo and radio. The tumor shranked 35% and she is doing fine. Having read many good things about DCA and your testimony, she really wants to try the DCA as you did and I am kindly requesting the following information from you. You will be saving a life if you could answer me:

        1) where did you buy the DCA?
        2) what dosage did you use and how (pills or intravenis)?

        Please reply to my personal e-mail:

        t.temel@uvt.nl

        I am impressed with your testimony and this DCA may be the cure many are waiting…

        Kind regards,
        Tugrul

        May 19, 2010
      • Chris #

        Good For you!!!! You are so right….. Now where can we get DCA?

        August 7, 2010
      • gee #

        hi judy,
        that was really an awesome story..my mom was diagnosed stage 4 esophageal cancer.we would so love to try that DCA if you can help me..where to get it and what dose..thanks very much..if you can e-mail me..Godbless..

        October 6, 2010
      • Mike #

        I was wondering, how much did you took per day and was it mixed in water?

        I am happy to read that you are now cancer free…Good job!

        Regards,

        Mike

        April 27, 2011
      • heams #

        Hi Judy, I would love to know which supplier you used as we are going to invest in some DCA for a family member who is suffering from cancer. Thanks so much, and congrats!

        July 4, 2012
      • Metapy #

        Im very happy for you, an your recovery. You were at the point of trying anything and fortunately you found a drug that does work. I agree with you, there is by far to much money being made on peoples suffering, an there needs to be a stop put to this practice. I have lost Father, his Mother, and severaal friends due to cancer, hopefully this is a breakthru that wil save numerous lives. Thank-you for sharing your story of recovery.

        October 14, 2012
    • Ang W Kiong #

      Greg, what then cures cancer? Chemotherapy that cause tens of thousands of dollars and causes the patients to lose hair and stay sick?

      How many cancer patients had chemeothegrapy saved all this years and what authentic evidence is there except those by the pharma crooks.

      Those who can afford, go ahead if you trust the doctor. What about patients who can’t afford it?

      For those who can’t afford it, shouldn’t they try out the many affordable therapy shared on the internet.

      It is not that mainstream chemeotherapy has no casualty.

      June 19, 2010
  2. Actually, you’re right. By the way, Orac writes
    Those of us who’ve been in the cancer field a while know that all too common are drugs that kill tumors in the Petrie dish and in mice or rats but fail to be nearly as impressive when tested in humans.

    I can’t find anything on the human effects of DCA. Where did you find those (pain, numbness…)?

    January 31, 2007
  3. greg #

    http://en.wikipedia.org/wiki/Dichloroacetic_acid#Adverse_effects
    I didn’t read it first on wiki, but i couldn’t find the original link, it was some sort of science site.

    January 31, 2007
  4. Thank you for the link! Greg, don’t you have a blog? I’d really be curious about your opinions, comments on the world’s things. :)

    January 31, 2007
  5. greg #

    Your welcome. Answering your question, I had a blog but it wasn’t too succesful. Maybe the opinions of an engineer student aren’t so interesting. Or I shouldn’t have written it in hungarian. (I like picking the latter reason, that saves me from beeing totally miserable :D ) Sad story, broke my hearth, you’ll never know how great author I am. :D

    February 1, 2007
  6. Mark #

    Try the link to the main info page.
    http://www.depmed.ualberta.ca/dca/
    the original article in the journal Cancer Cell, warning, it is information dense. After reading it, it seems highly legitimate, but needs to be replicated, and then trials on patients run to confirm.

    February 2, 2007
  7. Uh, thanks for the link! I’ll definitely take a deeper look at it today.

    February 2, 2007
  8. Markr #

    work by Stacpoole indicates that toxicity is probably linked to thiamine deficiencies. Possible other toxicities at higher doses to liver function relate to methionine deficiencies, and resulting DNA hypomethylation. Dose level seems to be critical, yet the doses for safe usage are known since it is commonly used for other conditions which cause lactic acidosis. Whether it works will only be determined by treatment of individuals with cancer. Many will have no hope left, so have nothing to lose.

    February 4, 2007
  9. Whether it works will only be determined by treatment of individuals with cancer.

    Yes, that’s not gonna happen in 10 years’ time… So even if it works, we won’t know about it.

    February 4, 2007
  10. lavon garrett #

    what are the side effects to DCA could you please elaborate on pain, numbness and gait

    February 7, 2007
    • Just neuropothy of the hands and feet but that goes away as soon as you quit taking DCA. With the chemo drug in R-CHOP, Vinchristine, it causes the same problem except the damage from vinchristine is permanant. DCA is the better bet.

      January 27, 2010
  11. You seem to have taken the letter writer’s statement as fact. Actually DCA has been used in treatment since the 1970s for metabolic disorders in children. Cancer research with Dichloroacetate has so far only been conducted in-vitro, but since the drug has been available for so long, I would expect that to change rapidly.

    For information on it’s use see:
    http://www.stanford.edu/group/hopes/treatmts/ebuffer/j4.html

    February 11, 2007
  12. Thank you for the link, this is the best review I’ve read on the subject.

    February 12, 2007
  13. Dose and duration are likely critical factors with respect to DCA side effects in humans.

    I wrote an article about DCA and found two recent studies with conflicting results regarding DCA-induced peripheral neuropathy.

    Stacpoole et al. (Pediatrics, 2006) ran a double-blind, randomized, control study of DCA in congenital lactic acidosis for 6 months using 25mg/kg/day and reported that oral DCA was well tolerated. However, Kaufmann et al. (Neurology, 2006) ended a 3-year cross-over clinical trial evaluating the efficacy of DCA in MELAS using 25mg/kg/day early due to peripheral nerve toxicity.

    A study published last month (Felitsyn et al., J Neurochem, 2007) using cultured rat Schwann cells and dorsal root ganglia neurons found that DCA caused a dose- and exposure-dependent decrease of myelination, which may account in part for DCA’s clinical peripheral neuropathic effects.

    February 12, 2007
  14. It’s time to update the article, thanks for sharing this…

    February 13, 2007
  15. Toni #

    I have been giving my sister in law dca for 2 weeks. She seemed to be getting a little better. She has 4th stage cancer. But today she was in a lot of pain and we noticed blood in her urine.
    Has anybody heard of this side affect if it is caused by dca or not.

    I was giviang her 250 mg 2 times a day and incfeased it on Sunday (3 days ago) to 3 times a day. Please e-mail any info to tristarmarketing@aol.com

    Toni

    March 7, 2007
  16. I sent an e-mail to you…

    March 7, 2007
  17. vijay #

    HI,
    I would like to know more about the efficacy and therapeutic effects of dichloroacetate. can it be adminstered along with chemotherapy for endometrial stromal sarcoma(high grade).

    March 9, 2007
  18. As just a medical student, I only can show you some interesting and relevant links on the subject:

    * Dichloroacetate safety
    * DCA Research Information
    * Wikipedia

    I hope that any of them could help.

    March 9, 2007
  19. lois scardina #

    please send me any information on the use of dca where to purchase it . what dosage is recommended etc.

    March 23, 2007
  20. Bill McKeag #

    I came across this blog quite by chance but it made be very happy that there are decent folk about just trying to help others on the internet and not looking for anything lese other than a thank you! So thanks to you all and God Bless any of you who have relatives afflicted with Cancer. Really interesting stuff on this DCA.

    March 27, 2007
  21. Dear Bill, these words assure my that I’m doing my job right. Thank you very much!

    March 28, 2007
  22. Anonymous #

    and how doesn´t want a Nobel, justified, preze?

    March 29, 2007
  23. Don #

    http://www.newscientist.com/channel/health/mg19325874.700-cheap-safe-drug-kills-most-cancers.html

    The above url is the site that refers to side effects of dichloroacetate.

    Is anyone familiar with Graviola or N-tense for treating cancers?

    hsibaltimore.com has some info. It is sold by http://www.raintreenutrition.com

    Hope this helps someone.

    There is also the Great Physician, Jesus Christ, who can heal anything!! Get to know Him!

    April 3, 2007
  24. Michael de Villiers (Canada) #

    On March 18, 2007, my beloved wife died at home from metastatic breast cancer. I watched her last 4 hours and saw, heard and winessed her last breath. I do not know whether DCA would have helped 2 years ago, but I know that my wife and I would have tried the drug… Please continue your good work and keep hammering at the doors of the FDA… The oil and drug industry own us all,making billions of profit through lies, deceit, fraud and price gouging. the oil and drug industries are the Bobsie twins.

    April 16, 2007
  25. Thank you for telling us your story, Michael! I’m trying to find relevant and new information about this drug.

    April 16, 2007
  26. gumaro #

    ko pienso de que esta droga debe tener algun efecto secundario que puede destruir las mismas celulas.

    April 20, 2007
  27. Das #

    Since DCA has been in use for metabolic disorders it might be worth looking to see if there is a lower incidence of cancer in the group that has been taking it compared to the general population. This may give a hunch as to whether it also works in humans. There are obvious caveats nonetheless the information may already be available.

    May 14, 2007
  28. It’s interesting what you’re saying. I have to take a deeper look at it to find something relevant.

    May 14, 2007
  29. Otto Sova, M.D., Ph.D. #

    I’m living at Slovakia and we try the DCA at brain cancer,at pancreas cancer and at goot cancer. The tumor in brain during two weeks of using of DCA in dichloracetatesodium salt, 25 mg / kg diminished of 15 %. Such a diminishing never ocured at any chemo or radiotherapy! At other two cases the control tests will be finished at the beginning of june I shall report again.

    May 15, 2007
  30. Wow! That’s interesting. Would you please make contact with me via e-mail? I’d like to ask you some questions berci.mesko [at] gmail.com

    Thank you in advance!

    May 15, 2007
  31. Greg Wren. #

    I have a patient with advanced prostate cancer. No other acceptable treatments, he is going to die. Understands this, and also understands possible consequences of DCA, and willing to trial it. 75kg body weight, will give him 30 mg per kg so 2.25 grams per day.
    Once daily, twice daily ???
    How long to continue for ???
    Until side effects, until cured, until notice no change ???.
    We have tried a lot of other natural therapies, no good. Last one was selenium ivi for 12 doses over 3 weeks. No change, tests still lousy and still in pain. Hopefully DCA will help.
    Can someone let me know the above questions? Thankyou so much.

    May 16, 2007
  32. I think this site answers your questions: http://thedcasite.com/dca_dosage.html

    May 16, 2007
  33. Tony MacDonald #

    My wife – the heart of my heart – has lung, liver, bone, and lymph nodes cancer. Ordered DCA today May 21,07. Will be here Friday. Will start Saturday morning. Starts radiation within 2 weeks; when she is strong enough she will start chemo. Will this drug be adequate during radiation and chemo…. If anybody has any answers please help me. Thank you. Will keep you briefed.

    May 21, 2007
  34. Dear Tony,

    DCA is the chemotherapy itself. I haven’t found any relevant information about DCA and radiotherapy, but if there is, it must be found on this site: http://thedcasite.com.

    I hope it helps.

    We’re with you and your wife!

    May 21, 2007
  35. Tony MacDonald #

    Question are there any anti oxidents in Dichoroacetate.The Radiation Oncology told me , to avoid any anti-oxidents while taking Radiation. can anyone answer this Question thank you

    May 23, 2007
  36. Tony, I think you should take a look at it: http://tinyurl.com/yo3unh

    May 23, 2007
  37. I’m glad to know that you have explored DCA in relation to cancer cure. I’m personally interested in these developments as one member of my family has cancer recurrence. I have written about it in my blog back in February 2007, although it was more of a brief note and pointing to information sites about it as I have no actual experience with it with patients. I’m hopeful about this development if only the potentially harmful side effects could be controlled.

    Tony, I am a member of the discussion forum at the DCA site. I have taken the liberty to post your question on DCA/antioxidants in relation to radiotherapy. I hope we get a comment or a thought soon. Keep the hope going!

    All the best.

    K

    May 23, 2007
  38. Here is a reply from the forum in DCA site regarding the use of DCA during radiotherapy.

    http://www.thedcasite.com/dcaforum/DCForumID1/55.html

    May 24, 2007
  39. mov #

    Can the supposed side-effects of DCA usage (pain,numbness,etc) be worse the ones due to chemo, radio or brachytherapy?
    Even if there is a semblance of hope from curing cancer the DCA way, I will be more than willing to volunteer. What’s the worst that testing DCA can do against not using it and letting cancer do it?!
    Appreciate if anyone can let me know commonly used products that have DCA it them.

    May 29, 2007
  40. I think you’ll find answers here:

    * Human Studies: http://tinyurl.com/yud2kx

    * DCA Safety: http://tinyurl.com/2486ug

    May 29, 2007
  41. hopefulnurse #

    I realize that Dr. Michelakis and his team at Alberta have more or less designated DCA as “theirs” or “his,” but I believe that studies and discovery of DCA happened long before rumor of DCA as a possible cancer treatment began circulation (among others, I know Dr. Stacpoole at UF has been doing extensive research with DCA- possibly even developed it- for decades. I haven’t found direct cancer related studies that he has done YET, but I seem to remember hearing some being rumored as either in process or in proposal).
    I understand and am sensitive to the fact that this could very well be an extremely important breakthrough for cancer patients, and I hope that it turns out to be as good as anyone could hope, but I am also aware of others in the medical community who seem a bit hesitant to glorify DCA to such an extent so soon. I can speak for no one but myself, but the media attention and the way that this has been put into public light so forcefully and so soon makes me a little uneasy. I appreciate that some believe that some hope is better than no hope at all, but is it right to advertise it in such a way as this? There’s a fine line of moral thoughtfulness and global repercussion when one is offering what seems to be more than just a glimmer of hope -indeed a possible cure- for something on such great a scheme as cancer. More studies need to be done, and that’s just it. Personally, I have enough hope in humanity that, be it cheap like DCA or not, the human community will find a way to make whatever cure surfaces to be accessible. So for me, that is not the immediate problem at hand. Sure, DCA might very well be a wonder drug; it might not. Time can seem incredibly cruel when something like this is tethered in front of so many in need, and I’m not at all to say that people shouldn’t try to take things into their own hands, but I can only hope that the only information read will be more than just what tells us what we want to hear- there’s a lot of talk of the same possibility, but it seems that skepticism becomes all to easily secondary.
    I hope that DCA is truly a leap towards a cure. If it is, then all of the attention that Dr. Michelakis has drawn for himself will not be in vain for all of those who now hang their hopes upon the fruit of his esteem.

    July 11, 2007
  42. You’re absolutely right (I mean absolutely!), that’s why I tried to be neutral in the article. Thank you for the valuable comment!

    July 15, 2007
  43. The cure for cancer is ANTIBODIES.

    A modified version of Dr. Donald L. Morton’s BCG treatment for bladder cancer will probably work in most cases. Here it is:

    A single CC of old-style (aqueous) tuberculin has to be injected into the tumour of a tuberculin-positive patient. That means, the patient must first have been vaccinated against TB. The tuberculin causes the tumour to become swollen, because of the immune reaction. IF OTHER TUMOURS OR METASTASES BECOME INFLAMED IN SYMPATHY, THE PATIENT IS CURED. Such inflammation can only be due to cancer antibodies.

    It is a cure because that variety of cancer will not come back.

    Another variant is to add new-style (alcohol-soluble) tuberculin to the old-style. This “marker” will not wash away so quickly, giving the immune system more time to latch on.

    As with the Morton bladder-cancer treatment, it may be repeated once a week for six weeks.

    Dichloroacetate may indeed be a successful treatment. There is a paucity of information on the subject. However, it is strictly a form of chemotherapy.

    Whenever a treatment extends the life of the patient, it allows the immune system time to “latch on” to the oncoprotein. Every cancer has altered DNA, and altered DNA produces altered protein – the oncoprotein. If dichloroacetate kills cancer cells, it is likely that whilst the immune system is cleaning up the debris, it might make the appropriate antibody.

    There is an excellent description of the workings of the immune system in “Lamarck’s Signature” (Professor Ted Steele et al.).

    Charles Douglas Wehner

    August 4, 2007
  44. Kim Martin #

    My name is Kim. My dad was diagnosed with Lung Cancer 4 months ago. He has had 6 radiation treatments, which shrunk the tumor by half. This past Monday he started a round of chemo. I can only hope and pray that he will get better. Any information on DCA or any other drug that may help my dad and many others out there fighting off this awful disease would be so greatly appreciated.

    September 27, 2007
  45. Jim Fairweather #

    09/27/07
    Below as information for those following the DCA issue.

    EDMONTON – Health Canada has approved the first human trial of an experimental cancer drug called dichloroacetate, or DCA, in people with an advanced form of an aggressive brain cancer.

    Shannon Montgomery, THE CANADIAN PRESS

    The molecule has drawn international attention after the University of Alberta’s Dr. Evangelos Michelakis published promising results in January showing it significantly shrunk tumours in rats. This new trial will give doctors a clue as to whether the research’s impressive results will make the jump into human subjects.

    “Typically from the time you report results in animals to the point that you test in a human being, takes about three years, even with the support of the pharmaceutical industry,” Michelakis said Wednesday. “For us to have completed it in eight months is remarkable.”

    Researchers hope to try the drug on up to 50 people with glioblastomas over the next 18 months. Michelakis said they are recruiting from the Edmonton area to start, but aren’t ruling out allowing people from other provinces to take part, as long as the funding can be found. The first subjects could begin within a few weeks.

    http://healthandfitness.sympatico.msn.ca/

    September 27, 2007
  46. Thank you, Jim, I update the article.

    Dear Kim, as a medical student, I can only show you some relevant links on the subject:

    * Dichloroacetate safety
    * DCA Research Information
    * Wikipedia

    I hope your father will get better soon!

    September 28, 2007
  47. BohaeTce #

    Hi I’m a Type-1 diabetic. Has anyone tried Methylglyoxal, Acai Berries, Green Tea catchecins, and DCA in combination? While researching AGEs and Diabetic conditions I came across an interesting site.

    —————-

    Indian Cancer Solution “Methylglyoxal”

    Indian cancer researchers have taken a giant step on the road to discovering a solution for cancer by developing a drug that selectively targets the cancer cells without harming the healthy ones.

    Researchers in Kolkata claim that patients in “very advanced stages” of cancer for whom all other treatments had failed have been brought back to “excellent” health with the help of a drug formulation they have developed after research spanning more than a decade.

    “We have what we think magic bullet against cancer,” says Manju Ray, a biochemist at the Indian Association of the Cultivation of Science (IACS) where the drug was developed under a project funded by the Department of Science and Technology and the Council of Scientific and Industrial Research.

    Most currently available anti-cancer drugs are toxic because they also damage the normal cells. Ray says the IACS formulation, containing “Methylglyoxal” as the lead ingredient, combats only the diseased cells, the cherished goal of cancer researchers worldwide. Methylglyoxal is a metabolite in the human body produced during glucose breakdown.

    Others involved in the project are Swapna Ghosh of IACS, Manoj Kar and Subhankar Ray of the University College of Science, and Santajit Datta, a medical practitioner. Results of human trial conducted by them with the new drug have recently appeared in the Indian Journal of Physics.

    While Americans are going ga-ga with their new anticancer drug “Glivec” – that was featured on the cover of May 28 issue of Time magazine – the low-profile, cash-strapped Kolkata researchers have been working quietly for over a decade shunning publicity until they obtained proof from human trials nine weeks ago.

    According to their published paper, the Methylglyoxal-based formulation had “a dramatic positive effect on the patients”.

    For instance, the condition of 11 out of the 19 patients treated – most of them in a very advanced stage when the treatment began — are now stated to be in “excellent physical condition”. Five are in stable condition and only three died during the course of the study.

    Since the submission of the paper, the number of patients treated has crossed 40 mark with more than 70 per cent success, according to Manju Ray.

    Most remarkable fact, according to the scientists was that Methylglyoxal was successful against different types of cancer unlike “Glivec” which targets only the chronic myeloid leukemia.

    Those whose health returned to “excellent” condition after treatment with Methylglyoxal included patients in “a very advanced stages” of colon cancer, acute myeloid leukemia, non-Hodgkin’s lymphoma, and cancers of ovary, breast, liver, lung, bone, gall bladder, pancreas and oral cavity.

    The patients were inducted for the trial, from January to June 2000, after obtaining permission from the Drug Controller General of India, the scientists said. The drug was administered orally for about six months with gradual reduction of daily dosage from the initial 25 milligrams per kilogram of body weight.

    Researchers said development of the drug was preceded by years of basic research involving human cancer cells in culture and animal experiments that showed that Methylglyoxal selectively killed the cancer cells without affecting normal cells by exploiting “a very significant” biochemical difference between the two.

    Explaining the mechanism of action, the scientists said cancer cells required a large amount of energy providing substance called ATP (Adenosine-5-Triphosphate) for survival.

    “Methylglyoxal inactivates the enzyme (Glyceraldehyde-3- Phosphate Dehydrogenase) needed for ATP production in cancer cells and thereby starves them to death. Normal cells remain unaffected.”

    Manju ray said that chemists knew Methylglyoxal molecule for about four decades and its anticancer effects in animals had also been studied. “But surprisingly, no one bothered to initiate further research leading to human trials,” she said.

    The researchers said concern in some quarters about safety of Methylglyoxal were not borne out from the clinical trials, which showed that in combination with protective agent like Ascorbic Acid and vitamins, the drug Methylglyoxal had no major toxic effect.

    They said there was scope for further enhancing the drug’s efficacy.

    Hindustan Times Hyderabaad May 28, 2001

    ——-

    http://www.biochemj.org/bj/323/0343/bj3230343.htm

    October 16, 2007
  48. BohaeTce #

    Brazilian berry destroys cancer cells in lab, UF study shows
    Filed under Research, Health, Sciences, Agriculture on Thursday, January 12, 2006.

    GAINESVILLE, Fla. — A Brazilian berry popular in health food contains antioxidants that destroyed cultured human cancer cells in a recent University of Florida study, one of the first to investigate the fruit’s purported benefits.

    Published today in the Journal of Agricultural and Food Chemistry, the study showed extracts from acai (ah-SAH’-ee) berries triggered a self-destruct response in up to 86 percent of leukemia cells tested, said Stephen Talcott, an assistant professor with UF’s Institute of Food and Agricultural Sciences.

    “Acai berries are already considered one of the richest fruit sources of antioxidants,” Talcott said. “This study was an important step toward learning what people may gain from using beverages, dietary supplements or other products made with the berries.”

    He cautioned that the study, funded by UF sources, was not intended to show whether compounds found in acai berries could prevent leukemia in people.

    “This was only a cell-culture model and we don’t want to give anyone false hope,” Talcott said. “We are encouraged by the findings, however. Compounds that show good activity against cancer cells in a model system are most likely to have beneficial effects in our bodies.”

    http://news.ufl.edu/2006/01/12/berries/

    October 16, 2007
  49. BohaeTce #

    I noticed Inositols (IP-6) is good and can be added to the list above:

    IP-6 Research Update
    Inositol hexaphosphate ( IP6 ): a novel treatment for pancreatic cancer.
    J Surg Res. 2005 Jun 15;126(2):199-203. Somasundar P, Riggs DR, Jackson BJ, Cunningham C, Vona-Davis L, McFadden DW.
    Louis A. Johnson VA Medical Center, Clarksburg, West Virginia; Department of Surgery, West Virginia University, Morgantown, West Virginia, USA.
    Inositol hexaphosphate (IP6) is a naturally occurring polyphosphorylated carbohydrate found in food sources high in fiber content. IP6 has been reported to have significant inhibitory effects against a variety of primary tumors including breast and colon. The effects of IP6 have not been evaluated in pancreatic cancer. We hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro.

    CONCLUSIONS: Treatment of pancreatic cancer with the common dietary polyphosphorylated carbohydrate IP6 significantly decreased cellular growth and increased apoptosis. Our findings suggest that IP6 has the potential to become an effective adjunct for pancreatic cancer treatment. Further in vivo and human studies are needed to evaluate safety and clinical utility of this agent in patients with pancreatic cancer.

    October 16, 2007
  50. BohaeTce #

    Caveat: Do not take SAMe or methylating factors if you already have cancer. The above study was done on animals, and pertains only to liver cancer. While it appears certain that methylation-enhancement will prevent cancer from starting, and while it looks very promising in liver cancer, not enough research has been done to show what happens when methylation-enhancing factors are taken during cancer. Most cancers are methionine-dependent. Patients with cancer should never take supplemental methionine.

    Methylation and Homocysteine

    SAMe is created in the body from methionine and ATP. When SAMe is used for methylation, a chemical reaction occurs where a methyl group is lost, and a by-product is created. This by-product is homocysteine. Homocysteine has gotten a lot of press recently as a culprit in heart attack and stroke. But homocysteine is not a bad thing in and of itself. Only when it’s allowed to accumulate does it start trouble.

    If things are going as they’re supposed to, homocysteine is converted to glutathione, a natural antioxidant, or back to methionine. If not converted, homocysteine can inhibit methylation.

    Elevated homocysteine causes lipid peroxidation and sticky platelets, both of which are associated with oxidation. It has been recently discovered that pigs with elevated homocysteine have abnormally high iron levels in heart muscle. Iron promotes free radical formation.

    Free radicals are not all bad. The body generates them for certain things. Surprising new research shows that homocysteine may help the immune system create the free radicals it uses to fight off invaders. Apparently, a gene that provokes the death of defective cells (apoptosis) begins the “destruct” process by increasing levels of homocysteine.

    There is some evidence that oxidative stress may impede methylation, and anything that reduces oxidative stress may enhance methylation. Researchers in Italy found that free radicals greatly reduce the synthesis of proteins, including lipoproteins. They attribute the decreased synthesis to under-methylation. Methylation is critical for protein synthesis, including the synthesis of lipoproteins such as cholesterol.

    Vitamins Lower Homocysteine

    The natural detoxification of homocysteine can happen only if enough B-vitamins are present. In order to convert homocysteine to glutathione, sufficient vitamin B6 must be present. In order to convert it to methionine, there must be enough folate and vitamin B12. These vitamins, along with TMG (trimethylglycine) which can also lower homocysteine, are called “methylating factors” because they increase SAMe and enhance methylation.

    Unfortunately, the American fast-food, meat-based diet is rich in methionine (meat) and poor in B vitamins (vegetables). The best sources of vitamin B6 and folate are unfrozen, uncanned vegetables and grains. Without the crucial B vitamins, homocysteine becomes a problem. High doses of certain vitamins decrease homocysteine by as much as 55 percent, according to a recent study published in Arteriosclerosis, Thrombosis and Vascular Biology.

    Methylation Deficiencies

    A person can’t go out and have his or her methylation measured. But the effects of under-methylation can be seen as premature aging, cancer, heart disease, liver disease and other chronic illness, depression and birth defects.

    Just as the body can become depleted of antioxidants, it can become methylation-depleted. Since SAMe is the number-one methylation substance, anything that depletes SAMe lowers methylation. Anything that interferes with the synthesis of ATP (such as alcohol) will deplete SAMe, as will aging. Lack of vitamins B6, B12 and folic acid will eventually deplete SAMe, and so will unusual demand.

    Aging decreases SAMe. As with free radicals, once under-methylation begins, it can snowball into a monster. All sorts of bad things can happen, from broken DNA to cancer, which brings up an important point.

    http://www.lef.org/magazine/mag98/aug98-report2.html

    October 16, 2007
  51. BohaeTce #

    http://www.arrowheadhealthworks.com/methgly.htm

    Many articles here on methylglyoxal and Cancer.

    October 16, 2007
  52. BohaeTce #

    Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy.

    Nat Med 2003 Mar; 9(3): 294-9.

    Hammes HP, Du X, Edelstein D, Taguchi T, Matsumura T, Ju Q, Lin J, Bierhaus A, Nawroth P, Hannak D, Neumaier M, Bergfeld R, Giardino I, Brownlee M.

    Three of the major biochemical pathways implicated in the pathogenesis of hyperglycemia induced vascular damage (the hexosamine pathway, the advanced glycation end product (AGE) formation pathway and the diacylglycerol (DAG)-protein kinase C (PKC) pathway) are activated by increased availability of the glycolytic metabolites glyceraldehyde-3-phosphate and fructose-6-phosphate. We have discovered that the lipid-soluble thiamine derivative benfotiamine can inhibit these three pathways, as well as hyperglycemia-associated NF-kappaB activation, by activating the pentose phosphate pathway enzyme transketolase, which converts glyceraldehyde-3-phosphate and fructose-6-phosphate into pentose-5-phosphates and other sugars. In retinas of diabetic animals, benfotiamine treatment inhibited these three pathways and NF-kappaB activation by activating transketolase, and also prevented experimental diabetic retinopathy. The ability of benfotiamine to inhibit three major pathways simultaneously might be clinically useful in preventing the development and progression of diabetic complications.

    ———–

    More results of the methlyglyoxal treatments with several B vitamins

    ————

    http://www.kanker-actueel.nl/sitemap/res_ca_nu.methylglyoxal.html

    October 16, 2007
  53. BohaeTce #

    Additional functions

    GAPDH is multifunctional like an increasing number of enzymes. In addition to catalysing the 6th step of glycolysis, recent evidence implicates GAPDH in other cellular processes. This came as a surprise to researchers but it makes evolutionary sense to re-use and adapt an existing proteins instead of evolving a novel protein from scratch.

    [edit] Transcription and apoptosis

    Zheng et al. discovered in 2003 that GAPDH can itself activate transcription. The OCA-S transcriptional coactivator complex contains GAPDH and lactate dehydrogenase, two protein previously only thought to be involved in metabolism. GAPDH moves between the cytosol and the nucleus and may thus link the metabolic state to gene transcription. [1]

    In 2005, Hara et al. showed that GAPDH initiates apoptosis. This is not a third function, but can be seen as an activity mediated by GAPDH binding to DNA like in transcription activation, discussed above. The study demonstrated that GAPDH is S-nitrosylated by NO in response to cell stress, which causes it to bind to the protein Siah1, a ubiquitin ligase. The complex moves into the nucleus where Siah1 targets nuclear proteins for degradation, thus initiating controlled cell shutdown. [2] In subsequent study the group demonstrated that deprenyl, which has been used clinically to treat Parkinson’s disease, strongly reduces the apoptotic action of GAPDH by preventing its S-nitrosylation and might thus be used as a drug. [3]

    ER to Golgi transport

    GAPDH also appears to be involved in the vesicle transport from the endoplasmic reticulum (ER) to the Golgi apparatus which is part of shipping route for secreted proteins. It was found that GAPDH is recruited by rab2 to the vesicular-tubular clusters of the ER where it helps to form COP 1 vesicles. GAPDH is activated via tyrosine phosphorylation by Src. [4]

    Cellular location

    All steps of glycolysis take place in the cytosol and so does the reaction catalysed by GAPDH. Research in red blood cells indicates that GAPDH and several other glycolytic enzymes assemble in complexes on the inside of the cell membrane. The process appears to be regulated by phosphorylation and oxygenation. [5] Bringing several glycolytic enzymes close to each other is expected to greatly increased the overall speed of glucose breakdown.

    http://en.wikipedia.org/wiki/Glyceraldehyde_3-phosphate_dehydrogenase

    ——————-

    Take Deprenel?

    Mech Ageing Dev 2002 Apr;123(8):1087-100
    Why (-)Deprenyl prolongs survivals of experimental animals: Increase of anti-oxidant enzymes in brain and other body tissues as well as mobilization of various humoral factors may lead to systemic anti-aging effects.
    Kitani K, Minami C, Isobe K, Maehara K, Kanai S, Ivy GO, Carrillo MC.
    National Institute for Longevity Sciences, 36-3, Gengo, Morioka-cho, Obu-shi, 474-8522, Aichi, Japan.

    (-)Deprenyl, a monoamine oxidase B (MAO B) inhibitor is known to upregulate activities of anti-oxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT) in brain dopaminergic regions. The drug is also the sole chemical which has been repeatedly shown to increase life spans of several animal species including rats, mice, hamsters and dogs. Further, the drug was recently found to enhance anti-oxidant enzyme activities not only in brain dopaminergic regions but also in extra-brain tissues such as the heart, kidneys, adrenal glands and the spleen. We and others have also observed mobilization of many humoral factors (interferone (INF)-gamma, tumor necrosis factor (TNF)-alpha, interleukine (IL)-1beta,2,6, trophic factors, etc.) and enhancement of natural killer (NK) cell functions by (-)Deprenyl administration. An apparent extension of life spans of experimental animals reported in the past may be better explained by these new observations that (-)Deprenyl upregulate SOD and CAT activities not only in the brain but also in extra-brain vital organs and involve anti-tumorigenic as well as immunomodulatory effect as well. These combined drug effects may lead to the protection of the homeostatic regulations of the neuro-immuno-endocrine axis of an organism against aging.

    http://www.anti-aging-guide.com/51deprenyl.php

    —————

    October 19, 2007
  54. BohaeTce #

    July 31, 2007
    From http://www.erieblogs.com/archives/2007/07/

    Inventor John Kanzius will share the latest updates on his groundbreaking cancer research project to area business and community leaders, during the Manufacturers’ Association’s monthly Eggs ‘n’ Issues briefing, Tuesday, July 31, at the Manufacturers’ Association of Northwest Pennsylvania (http://www.manp.org/) Conference Center, 2171 West 38th Street at 8 am.

    The Kanzius Non-invasive Radio Wave Treatment is a potential cancer therapy that uses high-energy radio waves to destroy cancer cells that have been “tagged” with nano particles. Nano particles attached to cancer cells are heated by radio waves to a temperature, which destroys the cancer cells. The technique is non-invasive, and can be provided without the need for auxiliary chemotherapy or radiation. Intensive and promising technological research about the Kanzius Radio wave Treatment is currently under way at M. D. Anderson Cancer Center in Houston, Texas, the University of Pittsburgh Medical Center, the Mayo Clinic and other American medical centers.

    ————-

    On Oct. 5, 2007, John said that “the largest research centers and nanoscientists in the world” are involved in this project.

    [edit]Inventor: John Kanzius
    Sanibel Island [Florida] resident John Kanzius is a former broadcast executive from Pennsylvania who wondered if his background in physics and radio could come in handy in treating the disease from which he suffers: cancer. A person witnessing the device asked him if it might desalinate water. When he ran an experiment using a test tube of salt water, the water began to burn.

    John Kanzius’ primary interest is in using this radio frequency nanotechnology to cure cancer. This Hydrogen-from-Salt Water discovery is but an interesting if not annoying detour for him.

    He invites interested parties to visit their lab to see a demonstration of the technology.
    ———–

    http://news.google.com/news?&q=kanzius

    October 19, 2007
  55. BohaeTce #

    Stimulation of Suicidal Erythrocyte Death by Methylglyoxal
    Jan Nicolay1, Juliane Schneider1, Olivier Niemoeller1, Ferruh Artunc1, Manuel Portero-Otin2, George Haik Jr.3, Paul Thornalley2, Erwin Schleicher4, Thomas Wieder1, Florian Lang1

    1Department of Physiology, and
    4Department of Internal Medicine, University of Tübingen,
    2Department of Biological Sciences, University of Essex,
    3George Haik Eye Clinic, New Orleans, Louisiana

    Address of Corresponding Author

    Cellular Physiology and Biochemistry 2006;18:223-232 (DOI: 10.1159/000097669)

    goto top of page Abstract

    Diabetes increases the percentage of circulating erythrocytes exposing phosphatidylserine (PS) at the cell surface. PS-exposing erythrocytes are recognized, bound, engulfed and degraded by macrophages. Thus, PS exposure, a feature of suicidal erythrocyte death or eryptosis, accelerates clearance of affected erythrocytes from circulating blood. Moreover, PS-exposing erythrocytes bind to the vascular wall thus interfering with microcirculation. The present study explored mechanisms involved in the triggering of PS exposure by methylgloxal, an extra- and intracellular metabolite which is enhanced in diabetes. PS exposure, cell size and cytosolic Ca2+-activity after methylglyoxal treatment were measured by FACS analysis of annexin V binding, forward scatter and Fluo-3-fluorescence, respectively, and it was shown that the treatment significantly enhanced the percentage of PS-exposing erythrocytes at concentrations (0.3 µM) encountered in diabetic patients. Surprisingly, methylglyoxal did not significantly increase cytosolic Ca2+ concentration, and at concentrations up to 3 µM, did not decrease the forward scatter. Instead, exposure to methylglyoxal inhibited glycolysis thus decreasing ATP and GSH concentrations. In conclusion, methylglyoxal impairs energy production and anti-oxidative defense, effects contributing to the enhanced PS exposure of circulating erythrocytes and eventually resulting in anemia and deranged microcirculation.

    Copyright © 2006 S. Karger AG, Basel

    http://content.karger.com/ProdukteDB/
    produkte.asp?Aktion=ShowAbstract
    &ProduktNr=224332&Ausgabe=232685&ArtikelNr=97669

    October 19, 2007
  56. BohaeTce #

    [Implication of methylglyoxal in diabetes mellitus]
    [Article in Romanian]

    Artenie A, Artenie R, Ungureanu D, Haulică I, Artenie V.

    Clinica a IV-a Medicală, Spitalul Clinic nr.2 C.I. Parhon Iaşi.

    Methylglyoxal (MG) is an early glycation product which is implicated in genesis of diabetic complications either as a direct toxin or as a precursor for advanced glycation end products. It is metabolized via S-D-lactoylglutathione to D-lactate by means of the enzymes glyoxalase I and II, which depend on glutattione as cofactor. MG is highly reactive and can bind to and modify proteins by chemical interaction with cellular proteins, action on energy production, induce free radical generation and cell killing. That way MG play a role in the events of the development of diabetic complications.

    http://www.ncbi.nlm.nih.gov/sites/entrez?
    Db=PubMed&Cmd=ShowDetailView&TermToSearch=
    14756009&ordinalpos=1&itool=EntrezSystem2.
    PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVAbstractPlus

    October 19, 2007
  57. I won’t lose hope. I hope more and more extensive follow up studies and tests shall follow through. This may not be the ultimate cure for now but at least the persons behind this cancer messiah already did a great initial step towards curing cancer.

    November 8, 2007
  58. There will never be an ultimate cure for cancer. All types of cancers must be treated in an individualized way. That’s why personalized medicine has a great future.

    November 8, 2007
  59. Do you feel bad now for recommending that DCA vendor site to those desperate people who read your blog?

    November 8, 2007
  60. Why should I, Mr. Gunn?

    November 8, 2007
  61. Before rejecting this drug, I hope FDA people would take a look at its mechanism or potentials instead of the price that goes with it. Sometimes we get more if we pay more.

    November 22, 2007
  62. Fran Perry #

    “Another year over-And a new one just begun” Anything that may look promising to assist or cure cancer-hey…sign me up! I’m sooo very tired of the toxins that go through my body during chemo. The medical community has discredited me for “asking” and “wanting” to know all that I can to make an informed decision, but have failed to satisfy or have gone as far as saying “I don’t have time” to answer those 3 questions (after making me wait 2 hours beyond my scheduled oncology appointment. I have had 3 oncologists for treatment over the past year. One who will order just about anything according to “standard regime”, no matter how it affects the patient, and then when things didn’t work out (severe allergic reaction for me), he wants to “continue” and in his own words “challenge me”. Thanks, but I want to live a little longer! Transferred to “new oncologist” who saw me a brief 2 visits over 8 months. She was either “too busy, on holidays, or on conference calls”, so was observed by her associates. After a brief encounter with a chemical (Oven Off), the Associate told me, the cancer was spreading! She made her sincere apologies. She informed me she could order a “chemo pill” as she has with a previous patient and is doing remarkably well now. No, I passed on the offer, went home and popped antihistimes all weekend. By Monday am, I was all better!!! I went back on the Friday and asked the oncologist “have you changed your mind about your diagnosis from last Friday?” She exclaimed “Absolutely! What did you do?” Well, I guess I cured my cancer with Antihistimines! maybe you should seek out that other female patient u spoke of and order her up some Antihistimines!
    Forgive me her, but sometimes these Drs. are thinking of what now? The best interest of their patients? Or are they truly overwhelmed at “what might be available to offer as options?” Getting back to my 2nd oncologist, Since Aug of 07, small leisons on the chest wall (recurrance of IBC with surgery & 4xAC,1xTax, 3xAC & 10 Herceptin) has now developed into 8 tumors along the scar line underarm. Treatment:Took away Herceptin – Wait & See Approach! What???? So, now I’m working on/with new Oncologist. Consult ended with: Back to Herceptin starting immediately, and a new regime of Vinorelebine? I am totally frustrated, annoyed Scared to no end, and I just want to be “healthy” again. Cure will never be part of my vocabulary, but to have something, anything that will support otherwise a healthy body, is it out there??? This DCA – would have to be a small step beyond Antihistimines, wouldn’t ya think??? lol I would be more than happy to try anything that would not compromise or jepordize the healthier side of what we are going through! So please, keep on searching, pls don’t discredit one’s accomplishments. They are so far & few between. And I always try to remember this “a little bit of something, is a whole lot better than nothing”. God Bless to All! Fran

    February 20, 2008
  63. WTF #

    Hmmmmm, let’s see….side effects VS dying of cancer

    February 24, 2008
  64. Not Waiting #

    To those who say “wait until the testing is complete and the FDA approves DCA,” I respond by saying:
    On the day you are diagnosed with cancer and given a life expectancy of maybe 2 to 5 years, then and only then can you say wait. And when you start waiting, then and only then, can you START to develop your new cancer cure using an inexpensive, non-patentable chemical that shows incredibly good promise for curing cancer, but no possible hope of earning back even the tiniest fraction of the cost of studies required for FDA approval.
    And by the way, while you’re waiting, you’re being pumped full of some of the most toxic chemicals known to man, and being bombarded with nearly lethal doses of radiation. You’re in pain or feel ill or are physically exhausted, experience sleep disorders, anxiety, depression, dehydration and untold other symptoms. But you get to keep waiting to even get the chance to try out your own cure while you’re trying to get the funding, organize and plan the studies… oh forget it… you’ll be long dead decades before your cure will ever come to market.
    But at least you won’t have to wait anymore.

    April 12, 2008
  65. tre #

    This is a cure soon to be out on the market I bet. Politics kill people.

    May 30, 2008
  66. Alfredo (SSG) #

    I’m interested in finding some DCA for my mother. We talked to a clinic in Canada and though the drug has not been used in any clinical trial there are ways of purchasing it there. Right now my mother has had tremendous shrinkage in her tumor and now her doctor wants her to continue chemo for an additional three cycles because they believe they can shrink the entire tumor. If things don’t go how they should I’m keeping all options open. The FDA, patents, and politics are killing people world wide and it sucks. The last thing cured in the world was polio and that is a shame. They are looking to make money off of death as oppose to trying to cure people.

    June 5, 2008
  67. Please read more about this alternative cancer treatment:

    http://www.treat-cancer.nl

    July 3, 2008
  68. Taking money form the sick is sick #

    http://www.treat-cancer.nl – Flavonoid cancer treatment protocol!!

    That is almost as effective as spinning in a circle with my thumb up my butt chanting “GO AWAY stage IIIb NSCLC”

    July 15, 2008
  69. this new wonder drug may be the cure for cancer but we still need a cure for the rich beurocrat

    July 26, 2008
  70. I am taking DCA and I am getting better. I have stage 4e Non-Hogekins lymphoma b cell sub category mantle cell, a slow deviding cell, and the DCA took care of the swelling the first week I was taking it, then my taste buds improved and my apetite returned, my night sweats went away (Oh man, that was well worth it) , the cancer smell is now gone after a few months, the itching went away, and, well, quite simply, if it doesn’t cure the cancer, it sure got rid of the obnauxious symptoms that made me so weak. I mean, I wasn’t sleeping good, but with the DCA, caffeine, B1 protocol, I am doing great and sleeping like a baby, which in turn gives me more energy! YEA for DCA! For lots of good info on DCA check out the DCA site at http://www.thedcasite.com and read to your hearts content. They have all the web links you need to educate yourself about DCA. They have been a Godsend to me. I thank them!

    July 31, 2008
  71. Anonymous #

    Hi Everyone
    Thanks for all the information you have posted. I still havent been able to find out how I can purchase DCA. Can anyone help me? I live in Australia. It is for my brother who has leukaemia and like many others, is at the stage where he will try anything. Thanks for the info and the consideration for my question…
    JR

    July 31, 2008
  72. JR, You might post your question on the DCA site at http://www.thedcasite.com and I am sure someone can help you find a source for DCA since you are in Australia. Many countries sell this and the site is most informative since people from all over the globe post there. That would steer you in the right direction, I’m sure. Best of luck! It is working for me. I have gone past my “expiration date” and I am in better shape now then I was when I was diagnosed with stage 4e lymphoma with bone marrow involvement. The best thing about DCA, it quickly stops the symptoms from the cancer. The night sweats went away immediately (well, within a weeks time), the smells, tastes, everything, even the itching skin. The best part was getting an appetite back for me! It is inexpensive (about 65.00 a month) and it will not be a dissapointment! Thanks and Good Luck. Tell your brother I said Get well, he will!

    August 5, 2008
  73. DCA attacks a unique feature of cancer cells, it cheap and safe drug that kills most cancers though it can cause pain, numbness and gait disturbances in some patients, but this may be a price worth paying if it turns out to be effective against all cancers.

    August 7, 2008
  74. valerie #

    Any info on DCA working on small bowel (jejunem) adenocarcinoma? Any info would be greatly appreciated.

    September 12, 2008
  75. I would like to know more about di-chloro acetate cancer treatment and some link to research article , thanks.

    September 28, 2008
  76. Timothy #

    Hello from a DCA patient whom has been taking this treatment for approximately one month. I want to set the story straight by posting my PET/CT scans and pathologists reports about my cancer. I came out of remission back in August of 2008. I only had 5 months without cancer since my first diagnosis back in June of 2007. I had stage 4 follicular lymphoma. In my initial PET Scan there was 100″s of tumors in my body, my pathologist report said to numerous to count on my kidneys alone. I did the RCHOP for 6 sessions in 3 months. I still had a cluster of cancer for about a month after my last chemo. In April my PET/CT scan was clear. But in August 2008 the cancer returned with a vengeance. At that time my oncologist suggested another round of high grade chemo, and stem cell replacement.I had 4 detectable tumors in my neck and sinus. 3 at 1.1 – 1.3 cm in my neck, and a 3.3cm tumor in my sinus are. Well I did my research and decided to try DCA. Went to the website http://www.thedcasite.com and started on October 10th 2008. Since then my night sweats have disappeared, my low grade fever is gone. My appetite has increased dramatically, hence the 5-7 pound weight loss per week has stopped. And we have noticed a SIGNIFICANT decrease in the tumors which are on my neck. I have not taken anything not even asprin since my last PET/CT so as to be an example for DCA once my next PET/CT scan is done in November. This will prove without a doubt from any oncologist, DR, or pathologist that DCA is the result of my tumors shrinking, the change in my physical and mental health, and put all the questions to rest that DCA does work and it is something that will help other cancer patients in their journey to live a symptom free life and work towards becoming a functioning, happy, and positive life individual again. And did I mention I have had NO side effects from the usage of DCA. Only a very positive attitude, and if I didn’t have the tumors I would never know I have cancer I feel so incredible. I will post a website with all my medical records for everyone to view, once I receive my next PET/CT scan.
    Timothy

    October 4, 2008
  77. Donna #

    I was diagnosed with malignant Angiomyolipoma 3 years ago, no chemo has worked but I have been kept alive by an amazing surgical oncologist and an amazing raditation oncologist. Seeing my cancer is so uncommon if not rare, no insurance company will allow me to try and new drugs. The tumors are starting reoccur every 3 months now and are primarily in my liver. The tumors grow fast once they form and future surgery and radiation may no longer be an option. Is there anyone out there who knows anyone diagnosed with this for options. I am due for another scan in 3 weeks and can feel that it won’t be good news. I do not want to die and am ready to try DCA if I can find it! To those of you who have decided to try DCA rather than “getting your affairs in order” please keep posting your progress, it is so encouraging… sincerely

    October 20, 2008
  78. I have advanced prostate cancer.
    I used DCA last year with hormone therapy (Casodex)
    My PSA came down from 227 to 12.
    I have not been using DCA for the past year and my PSA has increased to 29.54.
    As from yesterday iam back on DCA at the rate of 10mg/kg body weight. I think it works.
    My web site http://www.sarto-health.co.uk

    October 29, 2008
  79. Vohra #

    Dear Bertalan Meskó,
    My grandma (70 years old) is suffering from pancreatic cancer, she has a 2 1/2 inche tumour in her pancrease. The cancer cells have started spreading to her lungs. What do you think about her trying DCA? Should we consult her doctors about this drug? Please let me know soon.
    Thanks

    December 4, 2008
  80. My mom has tumor that has doubled in size in her liver . could you let us try this drug. Please help. Kemo is not working I think you are our only chance.

    December 7, 2008
  81. If you are looking for dca here another place to look for it:
    puredca.com

    December 9, 2008
  82. Donna #

    To Alex Zerbinos, I like your mom have liver tumors and they also did not respond to chemo, but have been kept alive for 3 years with radiation and surgery. Have you looked into this? Where are you located?

    December 19, 2008
  83. walter enang #

    Can someone please tell me where to get a reliable seller of DCA in Europe ?.My sister with stage 4 breast cancer is desperate for this wonderfulmedicine.
    You can email me directly at walterenang@gmail.com
    Thank you.

    January 15, 2009
  84. Hello. And Bye.

    February 12, 2009
  85. buc11 #

    I have similar question
    Can someone please tell me where to get a reliable seller of DCA in Europe or even in czech republic ?.My wife with stage 4 breast cancer is desperate for this wonderfulmedicine.
    Is it possible to buy DCA on internet? Which?
    You can email me directly at buc11@centrum.cz
    Thank you.

    February 20, 2009
  86. kai #

    DCA is a concept but has no valid human proof as of yet –
    but something that has been tested and does work is this:
    “Graviola Plant” its a natural cure with no or little side effects.
    it only targets the cancer cells and not the healthy cells,
    it reduces and often haults hair loss and it kills pain without
    the normal stomach upset or tumours associated with chemo.
    people who have been unwell to the point that they can no longer walk
    find that within several months of taking Graviola they can walk again,
    feel fit,healthy and strong,their hair grows back and the cancer growth haulted as well as it no longer spreading and if continued to use it will destroy the caner completely

    June 3, 2009
  87. Toni #

    I tried dca on my sister in-law. She was given 500 grams two times a day. It did absolutely no good at all. Within 3 months she was gone.
    It would be a miracle if all the hype was true, but this is just another researcher trying to getr attention.
    Why didn’t he run tsts on humans firdst and then tell us if it works or not. It is just false hope I’m afraid.
    But I will pray that someday somone will find a cure and screw the big drug companies on their useless medicine

    August 22, 2009
    • michael #

      wow 500 grams twice a day, thats is quite a bite considering DCA cost $140 for 100 grams and a person around 145 lbs only needs .8 of a gram per day as a normal dosage and the person needs so many days off as well in a course of a week or their body is overloaded with dead cancer cells which inturn poisons the body, 2 days on 1 day off or 2 days on and 2 days off or 5 days on and 2 days off is a normal course of action the days off are needed.

      February 22, 2010
      • nigeepoo #

        Toni probably meant milligrams.

        February 22, 2010
    • Ang W Kiong #

      I believe you get the dosage wrong. 500 mg or g? That it does not help yr sis[in[law, does it means that DCA is not useful. Besides, it is so much more affordable than what your doctor will prescribe.

      June 19, 2010
  88. Rob #

    I was diagnosed with metastatic colon cancer around May 1st 2009 and two oncologist gave me 6 months to a year to live without chemo and gave me an added year maybe with first line chemo. Five months later I have no symptoms, have had no chemo and two CT scans, one in July and one last week both showed significant reduction in the size of my tumors. Now my oncologist who wanted to give me chemo day one in May says no to chemo for two months at which time I get another CT scan. The only thing I have been taking is DCA, Sodium Dichoroacetate. I was very surprised when the first CT scan showed significant reductions but had NO faith that the second CT scan would show the same. Fully expected that my tumors had grown this time and expected to be on chemo this week. Now instead they are suggesting that I might be a candidate for surgery and chemo is on indefinite hold. DCA is working for me and I feel much better today than the first day I was diagnosed.

    October 2, 2009
    • Dear Rob,

      Could you tell us how you administered the DCA? Dosage, other medications or diet or supplements or vit B!, etc.

      Tugrul

      May 19, 2010
  89. VBeattie #

    Graviola has some interesting chemocytotoxic properties that bear research, but it should be noted that it can also have strong depressant effects on the cardiovascular system, in medium to large quantities acts as a violent emetic, and is known to cause uterine contractions and possible induced miscarriage. Be VERY careful when jumping on the “natural anticancer” bandwagon.

    I’d like to be cautiously optimistic about Dichloroacetate, but I’d like to see some specific, measurable, verifiable and repeatable research on human subjects before administering or recommending it to my loved ones. I’ll definately be checking in to see what the results of the glioblastoma tests are.

    Oh, and I believe that the peripheral neuropathy was only experienced in patients with preexisting mitochondrial disorders, such as mitochondrial cytopathy. I could be wrong, however.

    October 4, 2009
  90. backflip #

    I don’t understand people that say there is no research on dca. So they just believe people are making things up. Why are people so quick to judge scientist, biochemist, or just average americans or others trying to survive, we should all know it takes a incredible amount of effort to do any of this research and I congradulate all of you for trying in all the different ways you contribute! my mom was just given 6 months to live after having pancreatic surgery removing part of her pancrease, spleen, gallblader, they gave her 2 yrs on may 2009 and on october 2009 cancer spread to her liver and they have given her six months to live everyone know’s you die of pancreatic cancer and chemo never cures it. So what would the risks be of DCA again? tell me again! who cares! what about the risks of hair and teeth falling out intestinal illness -chemo kills plenty of people, sometimes it cures! If My mom wants dca or methylglyoxal- We wont just wait for a 10 years of research testing! It’s now or never!

    November 5, 2009
  91. A very difficult subject, which I would like to know more about it.

    November 20, 2009
  92. nigeepoo #

    Please note that red blood cells and liver cells rely on glycolysis to function. The liver has no defence against DCA. Therefore liver toxicity due to DCA is inevitable. However, the liver does have a defence against methylglyoxal (glyoxalase).

    Please also note that inhibition of glycolysis will cause cells to become insulin-resistant and stop taking in glucose. This can cause nerve & artery damage due to glycation. The solution to this “problem” is extremely simple – go on a low-carbohydrate or ketogenic diet. See http://high-fat-nutrition.blogspot.com/2009/11/methylglyoxal-on-atkins-uh-oh.html

    January 10, 2010
    • The neuropathy goes away as soon as the DCA is out of your system. Suppliments of Vit. B help eliminate that side effect. A Lot better than Vinchristine’s permanant damages (chemo in R-CHOP). I stayed on an alkaline diet while using DCA for 4 months. I am cancer free today. The DCA cleared up the bone marrow, and a BMT took care of the rest. I was stage 4E mantle cell lymphoma, non-hodgekins, B cell sub category mantle cell. Thanks.

      January 27, 2010
  93. Everyone please go to http://www.thedcasite.com and read all about DCA, people taking DCA, the University of Alberta in Edmonton’s human trials using DCA, and hey, Look at me, I am alive after being diagnosed with stage 4E Mantle cell lymphoma on Feb 1, 2007. They gave me 6 months, well here I am, Cancer free! almost 3 years now. I used the DCA from April 2007 until Oct.07 when I ran out and could not buy more because of the FDA’s ban on DCA. Then in Nov. 07, I could feel a new node in my neck (first one in my neck) so I had to do R-CHOP but before doing that, we found the bone marrow was clear of lymphoma. In Feb 07, it was 50% involved, so I had cancer in the bone marrow, took DCA, the DCA eliminated the symptoms of the cancer and cleared up my marrow. I was able to donate my own stem cells thanks to the DCA, and I am alive today after taking DCA and then having the BMT. Think of the possibilities, go to www dot The DCA site dot com (in case this page messes up url’s) with no spaces between the words, there are all the links you need to read the reports from the trials and more. Thank you. Judy Dowell

    January 27, 2010
  94. michael #

    my sister was diagnosed with Acute lymphoblastic leukemia in august of 2009 she went thru chemo and radiation and the leukemia went into remission in november she relasped one month later in december and went thru radiation and chemo for like 4 weeks and they couldnt get her leukemia into remission, so we brought her home to try our own treatment, they gave her a week to a month to live 2 weeks ago, we just started treating her with DCA yesterday so I will let you know how it works, she will recieve point 8 of a gram of DCA 2 days on 1 day off, along with 500 mg of B1, lots of caffiene, alpha laporic acid (sp?) fish oils, we also have been making her smoothies every day since she has been with 8 oz apple juice, frozen fruits, whey protien, 3 table spoons of coconut oil, banana, 2 tea spoons of Essiac, 2 tea spoons of L-glutamine plus 1 complete B vitamin pill which is blended right into smoothie, this makes her two glasses which she drinks thru out the day.
    She had a bad case of candida but the coconut oil clear that away, oh and we also have been giving her silver hydrosol

    February 22, 2010
    • Mado #

      Did the treatment work?

      September 1, 2010
    • Marina #

      Did it work? let us know. My husband is stage 4 colon cancer spread to liver, abdomen, lungs, etc. Traditional medicine has nothing else for him. Let us know whether it worked for you. My daughters (4 rs and 5 months old) could not possibly live w/o their daddy.

      May 17, 2011
    • heams #

      Hi Michael, can I ask how your sister is? Sounds like you all rallied around her to give her body a fighting chance at beating it :-) I am investigating DCA too. Thanks

      July 4, 2012
  95. b taylor #

    why bother with clinical trials and animal testing..cancer patients will die anyway..might as well give the victims some hope..but this will never pass to license..it is CHEAP and there is no PROFIT on it..so the victims will continue to suffer and die using toxins that kill the body before the cancer does..all because the pharm industry wants to make billion of profit.

    May 13, 2010
  96. I’m under the impression tha tearly forms of cancer can be cured by following proper nutrition and allowing your body to heal itself of disease.

    In later forms of cancer, the immune system is too weak to rebuild itself…

    August 26, 2010
  97. what is the problem, if laboratories want to make money then why dont they sell DCA at ridiculous prices, still it would save lives and would result better than letting people die, while keeping their money, if the problem is income the calculate the price required to make a profit and sell the damn thing.

    September 6, 2010
  98. ron #

    my name is ron my father has stage 4 small cell lung cancer i would like any info i could get on d c a where i can get it and how much to take

    September 25, 2010
  99. “Another year over-And a new one just begun” Anything that may look promising to assist or cure cancer-hey…sign me up! I’m sooo very tired of the toxins that go through my body during chemo. The medical community has discredited me for “asking” and “wanting” to know all that I can to make an informed decision, but have failed to satisfy or have gone as far as saying “I don’t have time” to answer those 3 questions (after making me wait 2 hours beyond my scheduled oncology appointment. I have had 3 oncologists for treatment over the past year. One who will order just about anything according to “standard regime”, no matter how it affects the patient, and then when things didn’t work out (severe allergic reaction for me), he wants to “continue” and in his own words “challenge me”. Thanks, but I want to live a little longer! Transferred to “new oncologist” who saw me a brief 2 visits over 8 months. She was either “too busy, on holidays, or on conference calls”, so was observed by her associates. After a brief encounter with a chemical (Oven Off), the Associate told me, the cancer was spreading! She made her sincere apologies. She informed me she could order a “chemo pill” as she has with a previous patient and is doing remarkably well now. No, I passed on the offer, went home and popped antihistimes all weekend. By Monday am, I was all better!!! I went back on the Friday and asked the oncologist “have you changed your mind about your diagnosis from last Friday?” She exclaimed “Absolutely! What did you do?” Well, I guess I cured my cancer with Antihistimines! maybe you should seek out that other female patient u spoke of and order her up some Antihistimines!
    Forgive me her, but sometimes these Drs. are thinking of what now? The best interest of their patients? Or are they truly overwhelmed at “what might be available to offer as options?” Getting back to my 2nd oncologist, Since Aug of 07, small leisons on the chest wall (recurrance of IBC with surgery & 4xAC,1xTax, 3xAC & 10 Herceptin) has now developed into 8 tumors along the scar line underarm. Treatment:Took away Herceptin – Wait & See Approach! What???? So, now I’m working on/with new Oncologist. Consult ended with: Back to Herceptin starting immediately, and a new regime of Vinorelebine? I am totally frustrated, annoyed Scared to no end, and I just want to be “healthy” again. Cure will never be part of my vocabulary, but to have something, anything that will support otherwise a healthy body, is it out there??? This DCA – would have to be a small step beyond Antihistimines, wouldn’t ya think??? lol I would be more than happy to try anything that would not compromise or jepordize the healthier side of what we are going through! So please, keep on searching, pls don’t discredit one’s accomplishments. They are so far & few between. And I always try to remember this “a little bit of something, is a whole lot better than nothing”. God Bless to All! Fran
    The neuropathy goes away as soon as the DCA is out of your system. Suppliments of Vit. B help eliminate that side effect. A Lot better than Vinchristine’s permanant damages (chemo in R-CHOP). I stayed on an alkaline diet while using DCA for 4 months. I am cancer free today. The DCA cleared up the bone marrow, and a BMT took care of the rest. I was stage 4E mantle cell lymphoma, non-hodgekins, B cell sub category mantle cell. Thanks
    On March 18, 2007, my beloved wife died at home from metastatic breast cancer. I watched her last 4 hours and saw, heard and winessed her last breath. I do not know whether DCA would have helped 2 years ago, but I know that my wife and I would have tried the drug… Please continue your good work and keep hammering at the doors of the FDA… The oil and drug industry own us all,making billions of profit through lies, deceit, fraud and price gouging. the oil and drug industries are the Bobsie twins.
    work by Stacpoole indicates that toxicity is probably linked to thiamine deficiencies. Possible other toxicities at higher doses to liver function relate to methionine deficiencies, and resulting DNA hypomethylation. Dose level seems to be critical, yet the doses for safe usage are known since it is commonly used for other conditions which cause lactic acidosis. Whether it works will only be determined by treatment of individuals with cancer. Many will have no hope left, so have nothing to lose.

    May 26, 2011
  100. angel #

    I have a large lump on my left breast. Tumor size is 8xcm by 2cm. I am desperate to get rid of this because its now obvious that my other breast is larger. I want to try DCA. Can anyone give me dosage about it? And food that I should eat and avoid? I am 42kg. Thanks.

    January 2, 2012
    • Mike #

      Hi Angel,
      Here’s a link that I hope will help you. I would also consider MMS.

      Good luck,

      Mike

      January 2, 2012
  101. angel #

    Hi Mike, thanks for the reply, by the way where is the link? Also what is MMS? Im not familiar with it..

    Thanks again

    January 2, 2012
    • Mike #

      By the way Angel, I saw some DCA Sodium Dichloroacetate that was quite cheap on Ebay from a seller that obviously already used some. Maybe the seller could provide you with more information.

      Good luck.

      January 2, 2012
  102. Anonymous #

    DCA sounds great. I heard about a similar substance called laetrile. Older people may remember the history of laetrile, and all the hopeful people that took it to rid themselves of cancer, and how it too didn’t go through clin trials. Many people were saved by laetrile, however even more payed tons of money for a treatment that was unsuccessful. Even worse, a third very large group was found, people that dies from the toxicity of the laetrile. Unfortunately, clin trials are necessary, and very expensive. Public domain drugs like DCA must be funded through the government because they cannot be profitable. Either the government or the medical industry, since insurance companies could see a financial benefit. But please, don’t use drugs for off-label treatment or terrible things could happen.

    January 11, 2012
  103. Ed Snyder #

    I have a close friend with advanced Melanoma, and another type in his liver, I will get some and see how it works with black tea and B1 as per the other sites instructions….
    I am angry that the country fathers have let Big Pharma take over the worlds health system.

    March 18, 2012
    • Anonymous #

      Hi ED Snyder
      Could you or anyone who recently used DCA let me know the effectiveness of it please?!! As I bought it for my mum who’s got colon cancer and I like to know more about it.
      Thanks

      May 17, 2012
      • Ed Snyder #

        Hi Anonymous,
        My friend left it far too late for this system to take effect.
        He died in May of a tumor obstructing his lower stomach, effectively stopping him passing poop. He could not hold down food, guess he really died of starvation mostly.

        July 6, 2012
  104. maria246 #

    my mum has glioblastoma i treat her with b17, metabolic diet, alkaline water, and i m going to add DCA. I was wondering if anyone has any experience or information regarding dosage in this combination.

    October 9, 2012
  105. Oh my goodness! Impressive article dude! Thank you so much, However I am experiencing troubles with your RSS.
    I don’t know why I am unable to join it. Is there anybody getting identical RSS issues? Anyone that knows the answer can you kindly respond? Thanks!!

    January 9, 2013
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    March 12, 2013
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    April 5, 2013
  108. Todd #

    Has anyone tried DCA for Chronic Leukemia CLL type B or know of a link showing if that had any good results. Currently my father is on LDN which has stabilized his condition. Thanks

    November 19, 2013
  109. Thanks for one’s marvelous posting! I certainly enjoyed reading it, you could be a great author.I will make sure
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    November 19, 2013

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