Comments on: SNPedia: DNA variations everywhere

By: Tarun Gupta

Tarun Gupta — Fri, 15 Aug 2008 22:32:42 +0000

Is it really worth identifying personal sequence variations while many confounding factors like environmental and dietary associations that may interfere in delineating disease susceptibility predictions, remain unknown. We still don’t understand the role and functional mechanism for each and every gene, nor do we understand the exact underlying molecular basis of each and every disease! And as Hsein puts it, common sense tells us that eating a lot of fat would give us cardiovascular complications even if we don’t have that spooky SNP!

By: My Biotech Life » Gene Genie #12 aka The Dozen

My Biotech Life » Gene Genie #12 aka The Dozen — Mon, 30 Jul 2007 00:35:33 +0000

[...] Genie founder himself, Berci from ScienceRoll presents us with yet another cool site based on the wiki system called SNPedia. The Gene Sherpa also has a nice review of this ever [...]

By: The Genetic Genealogist - » Interesting DNA News

The Genetic Genealogist - » Interesting DNA News — Thu, 26 Jul 2007 09:15:08 +0000

[...] posted about the SNPedia wiki, which is a database of information about human genome SNPs (single [...]

By: Bertalan Meskó

Bertalan Meskó — Tue, 24 Jul 2007 15:10:13 +0000

It’s getting more and more complicated. Thank you for the valuable comment, Ramunas! Maybe, one day, you should write about it on cancer.genetics.com.

By: ramunas

ramunas — Mon, 23 Jul 2007 21:29:57 +0000

i’m just 3years in this SNP’s world (had some project on artherosclerosis), but all these reported “associations, links etc.” findings have also the same amount of contra-data, where the SNP’s are found not be linked to certain disease. The solution: large scale collaborative international studies and metaanalyses for a wider application or local population based studies for local use.
And don’t forget that SNP, or polymorphism, it’s maily a statistical term – a variant which has a frequency more than 1% in a population. This definition tells you nothing about the clinical implication of this variant for a phenotype. Some currently nonpathogenic polymorphisms can turn into pathogenic one day, when more data accumulate. It a long way ahead, i think.