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Posts tagged ‘genetics’

MicroRNA and personalized medicine?

Barbara Duck from The Medical Quack blog shared a link with me yesterday and I was surprised to see how strong the connection is between personalized medicine and the world of microRNAs. MicroRNAs (miRNA) are single-stranded RNA molecules of about 21–23 nucleotides in length, which regulate gene expression; according to Wikipedia.

The link took me to the website of Rosetta Genomics, a company that was founded in Israel in 2000. From the FAQ:

Rosetta Genomics mission is to develop a novel class of diagnostics and therapeutics based on a recently discovered family of genes called microRNAs.

Rosetta Genomics is developing diagnostic and therapeutic products based on micro-ribonucleic acid, commonly known as microRNA, primarily for cancer and women’s health indications.

rosetta-genomics

They provide 3 diagnostic tests:

  • miRview Squamous: differentiates squamous from non-squamous non-small cell lung cancer
  • miRview  mets: dentifies the tissue-of-origin of metastatic tumors.
  • miRview  meso: differentiates malignant pleural mesothelioma from peripheral adenocarcinomas of the lung or metastatic carcinomas involving the lung pleura.

It will be interesting to see how they move forward with this concept.

And in case you need a miRNA search engine, here is Intragenic miRNA browser:

mirna-search

A picture worth a thousand words: Guess the diagnosis!

This picture is really worth a thousand words. I have a tip about the possible diagnosis, a genetic condition. What’s yours?

fragile-x

(Via Aequanimitas and  Clinical Cases and Images)

And have you seen the table of mug-shots featuring the members of the Personal Genome Project currently having their genomes sequenced? You can read more about it on Genetic Future as Daniel MacArthur has a lo of things to say:

pgp_mugshots

Top row from left: Misha Angrist, Keith Batchelder, George Church, Esther Dyson, Rosalynn Gill.
Bottom row from left: John Halamka, Stanley Lapidus, Kirk Maxey, Steven Pinker, James Sherley.

Real-Time Gene Monitoring and Family Trees

Medical News Today reported:

Imagine having GeneVision: the uncanny ability to view the activity of any chosen gene in real time through a specially modified camera.

With GeneVision, military commanders could compare gene expression in victorious and defeated troops. Retailers could track genes related to craving as shoppers moved about a store. “The Bachelor” would enjoy yet one more secret advantage over his love-struck dates.

A new study in BMC Biotechnology correlates real-time gene expression with movement and behavior for the first time. The proof-of-concept experiment in fruit flies opens a new door for the study of genes’ influence on behavior.

Sounds interesting, doesn’t it? With real-time gene monitoring, we could analyze the pathogeneses of diseases more accurately or watch the effects of specific drugs in real-time in vivo.

I also wanted to share a few other sites with you such as:

family-tree-dna-logo

  • FamilyBuilder: they offer a YDNA test kit for males only, and an mtDNA test kit for both males and females.

family-builder-logo

I’m about to build a database of useful genetics-related links so feel free to share any promising sites/services with us.

Gene Genie #41: Carnivalome

Gene Genie is the blog carnival of clinical genetics and personalized medicine. I’ve received more than 25 submissions for this edition which is dedicated to the human genome and videos in clinical genetics.

gene_genie_logo_400.jpg

Many thanks to Ricardo Vidal for the logo!

The molecular level:

Daniel MacArthur at Genetic Future wrote about Genetics of gene expression in African-Americans: ominous news for personal genomics?

Alex Palazzo at The Daily Transcript analyzed 100 years of genetic research.

Greg Laden‘s submission was The Scientific, Political, Social, and Pedagogical Context for the claim that “Race does not exist.”

Larry Moran at Sandwalk talked about Genes and Straw Men

The clinical level:

Chavonne Jones at Human Genetics Disorders shared Muscular Dystrophy Gene Therapy Video:

The Daily Scan informed us about Breaking Cancer’s Gene Code.

Walter Jessen at Highlight Health focused on Potential Location of Autism Genes Identified and Gene Expression Can Predict the Survival of Lymphoma Patients.

The PHG Foundation posted about Helping physicians understand genetic risk and Epilepsy Phenome / Genome Project.

Grace Ibay at Genetics and Health published two interesting articles: Gene therapy research presents hope for sickle cell anemia and The genetic disorder that kept her from dancing.

Chavonne Jones at Human Genetics Disorders also shared a Wilson’s disease video with us:

The personalized genetic level:

The Navigenics Blog said Leading genomic researcher discusses his own test results.

Hsien-Hsien Lei at Eye on DNA unveiled Singapore Company DNA Dynasty Will (Not) Tell Your Children’s Future.

Do you know costs are plummeting for human genome sequencing?

The PredictER Blog focused on genetic privacy.

Daniel MacArthur at Genetic Future featured advice for doctors on dealing with personal genomics customers.

Read more about The Spitterati and Trickle-Down Genomics at the site of Center for Genetics and Society.

Blaine Bettinger at The Genetic Genealogist analyzed Familybuilder that announces DNA Testing.

Now: The rest of the genome (Herald Tribune).

Lygeia Ricciardi at Project HealthDesign asked “Would knowing your genes change how you act?

And don’t miss the Book of Me.

Genetic Testing for Heart Disease:

The President level:

The Genetic Privacy of Presidential Candidates (New England Journal of Medicine):

Using genetic information to disparage opponents has no place in presidential campaigns. Nonetheless, the threat of genetic McCarthyism provides us with an opportunity to engage in a public dialogue about the limitations and complexities of using genomic information for decisions about life and health — including voting for our president.

Gene Screen: Will We Vote Against a Candidate’s DNA? (Wall Street Journal):

“DNA is not an issue in this campaign, but in the next campaign it will be bigger,” says George Annas, a leading authority on bioethics and human rights at Boston University. “It’s coming.”

If you want to host an issue of Gene Genie in 2009, let me know (berci.mesko [at] gmail.com). Don’t forget to submit your articles (berci.mesko [at] gmail.com).

And also check the Gene Genie blog out!

My Generation Health: Genetic testing first!

There are many personalized genetic services nowadays, but I think only a few of them have a strong future (Helix Health, Navigenics and 23andMe). Now here is a new candidate, My Generation Health.

my-generation-health

Generation Health is a health management company that specializes in helping employers and other health care payors manage medical costs and improve their employees’ and members’ health by assuring optimal utilization of genetic testing. Just as pharmacy benefit managers (PBMs) arose in the 1980’s to help health care payors better manage their pharmacy expenditures, Generation Health recognizes the need for a genetic testing benefit manager to be a trusted third party that can help payors manage this increasingly complex field. Clients will realize value in several ways:

  • Establishing a framework and rationale for covering and excluding specific genetic tests, based upon clinical validity and utility.
  • Prior authorization of all covered tests for eligible employees based upon sound medical criteria.
  • Negotiating discounted testing prices and quality/service standards with a contracted network of genetic testing labs.
  • Identifying patients, through analysis of medical and prescription claims, who may benefit from genetic testing, and then facilitating their testing.

(Via Lab Soft News)

Do you think it has a future?

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