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Gene Genie #42 at Genetic Future

The  42nd edition is up at Genetic Future. A great compilation of articles and blogposts about human genetics and personalized medicine. Thank you, Daniel MacArthur, for hosting Gene Genie.

Gene Genie is the blog carnival of genes and gene-related diseases. Our plan is to cover the whole genome before 2082 (it means 14-15 genes every two weeks). We accept articles on the news of genomics and clinical genetics. The news and articles of personalized genetics are also included. Check out Gene Genie for more about this unique field of medicine.

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Many thanks to Ricardo Vidal for the logo!

Don’t forget to submit your articles via e-mail (berci.mesko at gmail.com).

Let me know if you would like to host an edition.

Here are all the issues of Gene genie:

2009 Predictions in Personalized Genetics

Hsien-Hsien Lei shared her 2009 predictions about personalized genetics with us and that’s where I would like to leave a few comments.

1. 23andMe will begin selling their tests on drugstore shelves.

I think they would be sued soon.

2. President Barack Obama will be offered genome sequencing.

He cannot and mustn’t accept it.

3. Apple will launch iSEQ – instant DNA testing and analysis in a handheld device.

I don’t think Apple will ever enter this market.

4. The first 10 participants in the Personal Genome Project will band together to be called Fantastic Ten. Each will reveal secret superpowers that are embedded in their DNA.

That is a possibility. But if they think wisely, they will never do something like that.

5. The U.S. government passes laws to obtain DNA from all its citizens which it says will help protect the innocent and punish criminals.

It was only possible in Iceland and will never be possible in the US.

What I think about 2009 is that Navigenics will rule the market even if its service is more expensive than the kit of 23andMe.

navigenics

Further reading:

AccessDNA: Know Your Genetics

I’ve recently discovered AccessDNA on Twitter and I thought I should give it a try. On the main page, it says I should create my personalized report. Well, let’s do so.

accessdna

It asked me about the medical conditions that occurred in my family; environmental factors I have to face; tests I would be interested in, etc. And then I received the personalized genetic report; actually a list of genetic tests that might be useful for me.

accessdna-report

What can I do with that information? Yes, of course I want full genome scanning. But should this be my decision? Not the decision of my doctor? Just beacuse I reported to be of Caucasian descent, I should order genetic tests that cost several thousands of dollars?

You know what? I would love to hear the opinion of Steve Murphy here. And yours!

MicroRNA and personalized medicine?

Barbara Duck from The Medical Quack blog shared a link with me yesterday and I was surprised to see how strong the connection is between personalized medicine and the world of microRNAs. MicroRNAs (miRNA) are single-stranded RNA molecules of about 21–23 nucleotides in length, which regulate gene expression; according to Wikipedia.

The link took me to the website of Rosetta Genomics, a company that was founded in Israel in 2000. From the FAQ:

Rosetta Genomics mission is to develop a novel class of diagnostics and therapeutics based on a recently discovered family of genes called microRNAs.

Rosetta Genomics is developing diagnostic and therapeutic products based on micro-ribonucleic acid, commonly known as microRNA, primarily for cancer and women’s health indications.

rosetta-genomics

They provide 3 diagnostic tests:

  • miRview Squamous: differentiates squamous from non-squamous non-small cell lung cancer
  • miRview  mets: dentifies the tissue-of-origin of metastatic tumors.
  • miRview  meso: differentiates malignant pleural mesothelioma from peripheral adenocarcinomas of the lung or metastatic carcinomas involving the lung pleura.

It will be interesting to see how they move forward with this concept.

And in case you need a miRNA search engine, here is Intragenic miRNA browser:

mirna-search

A picture worth a thousand words: Guess the diagnosis!

This picture is really worth a thousand words. I have a tip about the possible diagnosis, a genetic condition. What’s yours?

fragile-x

(Via Aequanimitas and  Clinical Cases and Images)

And have you seen the table of mug-shots featuring the members of the Personal Genome Project currently having their genomes sequenced? You can read more about it on Genetic Future as Daniel MacArthur has a lo of things to say:

pgp_mugshots

Top row from left: Misha Angrist, Keith Batchelder, George Church, Esther Dyson, Rosalynn Gill.
Bottom row from left: John Halamka, Stanley Lapidus, Kirk Maxey, Steven Pinker, James Sherley.

Real-Time Gene Monitoring and Family Trees

Medical News Today reported:

Imagine having GeneVision: the uncanny ability to view the activity of any chosen gene in real time through a specially modified camera.

With GeneVision, military commanders could compare gene expression in victorious and defeated troops. Retailers could track genes related to craving as shoppers moved about a store. “The Bachelor” would enjoy yet one more secret advantage over his love-struck dates.

A new study in BMC Biotechnology correlates real-time gene expression with movement and behavior for the first time. The proof-of-concept experiment in fruit flies opens a new door for the study of genes’ influence on behavior.

Sounds interesting, doesn’t it? With real-time gene monitoring, we could analyze the pathogeneses of diseases more accurately or watch the effects of specific drugs in real-time in vivo.

I also wanted to share a few other sites with you such as:

family-tree-dna-logo

  • FamilyBuilder: they offer a YDNA test kit for males only, and an mtDNA test kit for both males and females.

family-builder-logo

I’m about to build a database of useful genetics-related links so feel free to share any promising sites/services with us.

Gene Genie #41: Carnivalome

Gene Genie is the blog carnival of clinical genetics and personalized medicine. I’ve received more than 25 submissions for this edition which is dedicated to the human genome and videos in clinical genetics.

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Many thanks to Ricardo Vidal for the logo!

The molecular level:

Daniel MacArthur at Genetic Future wrote about Genetics of gene expression in African-Americans: ominous news for personal genomics?

Alex Palazzo at The Daily Transcript analyzed 100 years of genetic research.

Greg Laden‘s submission was The Scientific, Political, Social, and Pedagogical Context for the claim that “Race does not exist.”

Larry Moran at Sandwalk talked about Genes and Straw Men

The clinical level:

Chavonne Jones at Human Genetics Disorders shared Muscular Dystrophy Gene Therapy Video:

The Daily Scan informed us about Breaking Cancer’s Gene Code.

Walter Jessen at Highlight Health focused on Potential Location of Autism Genes Identified and Gene Expression Can Predict the Survival of Lymphoma Patients.

The PHG Foundation posted about Helping physicians understand genetic risk and Epilepsy Phenome / Genome Project.

Grace Ibay at Genetics and Health published two interesting articles: Gene therapy research presents hope for sickle cell anemia and The genetic disorder that kept her from dancing.

Chavonne Jones at Human Genetics Disorders also shared a Wilson’s disease video with us:

The personalized genetic level:

The Navigenics Blog said Leading genomic researcher discusses his own test results.

Hsien-Hsien Lei at Eye on DNA unveiled Singapore Company DNA Dynasty Will (Not) Tell Your Children’s Future.

Do you know costs are plummeting for human genome sequencing?

The PredictER Blog focused on genetic privacy.

Daniel MacArthur at Genetic Future featured advice for doctors on dealing with personal genomics customers.

Read more about The Spitterati and Trickle-Down Genomics at the site of Center for Genetics and Society.

Blaine Bettinger at The Genetic Genealogist analyzed Familybuilder that announces DNA Testing.

Now: The rest of the genome (Herald Tribune).

Lygeia Ricciardi at Project HealthDesign asked “Would knowing your genes change how you act?

And don’t miss the Book of Me.

Genetic Testing for Heart Disease:

The President level:

The Genetic Privacy of Presidential Candidates (New England Journal of Medicine):

Using genetic information to disparage opponents has no place in presidential campaigns. Nonetheless, the threat of genetic McCarthyism provides us with an opportunity to engage in a public dialogue about the limitations and complexities of using genomic information for decisions about life and health — including voting for our president.

Gene Screen: Will We Vote Against a Candidate’s DNA? (Wall Street Journal):

“DNA is not an issue in this campaign, but in the next campaign it will be bigger,” says George Annas, a leading authority on bioethics and human rights at Boston University. “It’s coming.”

If you want to host an issue of Gene Genie in 2009, let me know (berci.mesko [at] gmail.com). Don’t forget to submit your articles (berci.mesko [at] gmail.com).

And also check the Gene Genie blog out!

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